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The GLP-1 medications such as semaglutide, Ozempic, Wegovy, tirzepatide, Mounjaro and Zepbound are likely to be the most impactful medications to become available in the United States in my career! The semaglutide and tirzepatide medications have been revolutionary in the battle against obesity. Initially developed as treatments for diabetes, these medications have shown profound effects on weight loss. Patients have experienced weight loss amounting to between 15% and 20% of their body weight within a year, leading to a global impact.