hyperpigmentation

Retinoic Acid Inhibits Melanocytes

A study published in the Japanese Dermatological Association Journal of Dermatology (January 2017) examined the in vitro effects of all-trans retinoic acid (ATRA) on human melanocytes and melanoblasts following treatment with different concentrations and/or an antagonist of the endothelin B receptor (EDNRB, bosentan). The experiments were all repeated at least four times, and data was analyzed via the Mann-Whitney U-test.

Cutera Launches PICO Genesis

Cutera has introduced the PICO Genesis, a new nonthermal approach for the treatment of pigmentary skin concerns using the Enlighten picosecond laser system. The procedure uses ultra-short laser pulses that deliver a shockwave effect to selectively shatter pigment, and disrupt and remodel the upper dermis for a brighter, more uniform complexion. It takes about 20 minutes from start to finish, is pain-free and requires very little downtime.

A Clear Outcome

Reducing the risk of post-inflammatory hyperpigmentation following skin resurfacing treatments.
A Clear Outcome

Post-inflammatory hyperpigmentation (PIH) is one of the most common adverse events seen in patients who undergo laser or chemical peel resurfacing. The cutaneous inflammation caused by the heat and/or epidermal injury leads to an overproduction of melanin. Providers can reduce the risk of PIH by recognizing high-risk patients and prescribing comprehensive pre- and postprocedure skincare regimens.

Treating PIH With IPL

Treating PIH With IPL

A study published in Dermatologic Surgery (February 2016) examined the safety and efficacy of a novel pulse-in-pulse mode intense pulsed light (IPL) for the treatment of persistent facial post-inflammatory hyperpigmentation (PIH).

Hyperpigmentation Linked to Vascularity

Hyperpigmentation Linked to Vascularity

A study published in the Journal of Investigative Dermatology (December 2015) addressed the link between pigmentation and vascularization in melasma and hyperpigmentation. Using high-magnification digital epiluminescence dermatoscopy, laser confocal microscopy and histological examination, Claire Regazzetti, et al, demonstrated that benign vascular lesions have restricted but significant hyperpigmentation compared with the surrounding skin.

Tone It Down

Top modalities for treating hyperpigmentation.
Tone It Down

In medical aesthetics, there are a wide variety of treatments geared toward reducing wrinkles and replacing lost volume. But what we have learned over the years is that pigmentation problems are, in fact, one of the most noticeable signs of aging.

Retinoids Effective in Reducing Melasma

A new topical product featuring a combination of retinoids offers results comparable to hydroquinone in patients with facial melasma. Maria Teresa Truchuelo MD, PhD, Natalia Jimenez, MD, and Pedro Jaen, MD, PhD, of the dermatology department at University Hospital Ramon y Cajal in Madrid, Spain, performed a prospective, double-blind, vehicle-controlled, and randomized study in 30 patients with melasma. Sibjects applied the combination retinoid product on one side of their faces and the vehicle on the other. Product was applied twice daily for three months.

Broad A-Peel

Chemical peels can address numerous concerns, but achieving optimal outcomes requires an understanding of skin types, peeling agents and appropriate post-peel care.
Broad A-Peel

Few treatment modalities have the ability to treat as wide a variety of patients and concerns as chemical peels. Whether an individual wants to reduce fine lines and wrinkles, get rid of facial scarring or knock down cystic acne, there is a peeling agent that can help.

Skin Care: Advanced Hyperpigmentation Relief

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Advanced Hyperpigmentation Relief

SkinCeuticals Advanced Pigment Corrector clears and brightens skin by exfoliating existing spots at the stratum corneum, inhibiting melanin transfer at the epidermis and blocking excess melanin production at the basal layer. Key ingredients include 0.3% salicylic acid, 1% hydroxyphenoxy proprionic acid—a nontoxic derivative of hydroquinone, 0.5% ellagic acid and 4% yeast extract. Contact: 800.771.9489, www.skinceuticals.com

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Skin Care Researchers Seek Natural Extracts To Regulate Pigmentation

SkinMedica teams with the MGH Cutaneous Biology Research Center to search for natural extracts that can safely and effectively modulate melanin production and deposition.
Skin Care Researchers Seek Natural Extracts To Regulate Pigmentation

“It’s a bit like looking for a needle in a haystack,” says David Fisher, MD, PhD, chief of the Massachusetts General Hospital (MGH) Department of Dermatology and director of the MGH Cutaneous Biology Research Center, in reference to the collaboration agreement his department recently signed with SkinMedica (www.skinmedica.com). The research group will be evaluating tens of thousands of natural extracts. “We are actually seeking at least two agents: one that can safely and effectively lighten unwanted pigmentation and one that can safely darken light skin,” he says.