Photothermolysis With Silver Particles

Two small-scale studies highlight the potential of silver particles to improve the efficacy of laser hair removal and light-based acne treatments.
MedEsthetics July/August 2017 Newsmakers

As aesthetic treatments become more varied and efficacious, there remain some key gaps in treatment options. For example, laser hair removal is one of the most pop­ular services offered in aesthetic practices and medspas, yet permanent hair reduction is not an option for those with blonde and red hair. Dermatologists have long sought an alternative to systemic treatments for those with moderate-to-severe acne, and while laser treatments have shown promise, their efficacy is short-lived and inconsistent.

Factors Associated With Adult Female Acne

Factors Associated With Adult Female Acne

A study published in the Journal of the American Academy of Dermatology (December 2016) sought to explore the role of personal and environmental factors in the development of adult female acne.

Researchers Anna Di Landro, MD, et al, conducted a multicenter case-control study, which included 518 women treated in outpatient dermatology departments of 12 Italian cities. They investigated 248 consecutive women ≥25 years of age with newly diagnosed acne of any grade. Women diagnosed with conditions other than acne (n = 270) acted as controls.

Novan Phase 3 Pivotal Trials Fully Enrolled

Novan has announced that the last patient has been randomized in its two identically designed Phase 3 pivotal clinical trials to evaluate the efficacy and safety of topical nitric oxide-releasing product candidate SB204 gel for the treatment of acne vulgaris. More than 2,600 subjects have been enrolled ahead of schedule, and Novan expects to report top-line results in the first quarter of 2017.

The company’s Phase 3 program includes three studies:

FDA Approves Differin Gel For OTC Acne Use

FDA Approves Differin Gel For OTC Acne Use

Galderma Laboratories has received approval from the U.S. Food and Drug Administration (FDA) for Differin Gel (adapalene gel 0.1%) as an over-the-counter (OTC) treatment for acne—the first and only OTC acne product containing a full prescription-strength retinoid. It also marks the first new, FDA-approved active ingredient to be introduced to the OTC acne category in more than three decades. Differin Gel is a once-daily topical indicated to treat current and future breakouts in people age 12 and older. The 0.1% adapalene gel is clear, fragrance-free, oil-free and alcohol-free.

Topical Minocycline Yields Positive Results

Specialty pharmaceutical company BioPharmX announced topline results from its Phase 2a safety study of BPX-01, a hydrophilic topical gel formulation of solubilized minocycline. The results showed the product reported no cutaneous toxicity and resulted in no adverse effects. The study also revealed that the gel left no detectable levels of minocycline in the patients’ bloodstreams, which suggests that a much lower dose of minocycline applied topically has the potential to treat acne without the side effects normally associated with the oral form of the antibiotic.